Release date: 2010-10-25
Recently, the tumor-specific activation amplification system (VISA system) invented by Xie Xiaoming, director of the Breast Department of the Cancer Center of Sun Yat-sen University, obtained the invention patent certificate issued by the US Patent and Trademark Office (USPTO).
One of the most studied pathways in molecular targeted therapy is targeted transcriptional technology, which uses tissue and cell-specific promoters to control the transcription of genes, thereby allowing therapeutic genes to be expressed in specific cells for therapeutic purposes. The ideal specific regulatory sequence should be characterized by high tissue or tumor specificity, no leakage, regulatable, and efficient initiation of foreign gene expression in target cells.
Xie Xiaoming's research on VISA system significantly increased transgene efficiency and specificity index, enhanced gene targeting, and successfully solved the key scientific problems of low tumor-specific promoter activity in gene therapy. It has been confirmed by experiments that the VISA system enhances the tumor-specific promoter activity by 600-700 times, significantly enhances the gene therapy specificity index; prolongs the expression time by 3-4 times, significantly increases the efficacy of gene therapy, reduces the number of doses and the effective dose. , that is, enhanced targeting. The VISA system has important value and application prospects in gene regulation, efficient gene expression and development of biological products, targeted gene therapy and the establishment of new animal Models. At present, the system has been applied by dozens of laboratories in the United States, Britain, Japan, South Korea and Taiwan.
Source: Bio Valley
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