British scientists reported in the United States "Science" magazine published on the 23rd that they used transgenic technology to breed mice with congenital dementia (also known as Down syndrome), providing clues for studying the disease and similar chromosomal diseases. .
Abnormalities were found on chromosome 21 in patients with congenital dementia. Most patients had 3 chromosomes 21. In a small number of patients, there were 3 replicates in certain regions of the chromosome. About one in 750 newborns will have congenital dementia, 40% will have congenital heart disease, and patients will have high rates of leukemia and Alzheimer's disease.
Researchers at the National Institute of Medicine and the University College London reported that they first extracted chromosome 21 from the human body and injected the chromosomes into mouse embryonic stem cells. Only one chromosome was injected into each embryonic stem cell. Then they injected these stem cells into mouse embryos and implanted them in female mice. The transgenic mice born in females carry about 92% of the human chromosome 21 genes and show signs of congenital dementia such as learning and memory deficits.
The researchers said they will use this transgenic mouse to search for genes specific to the control of congenital dementia on chromosome 21. This study helps scientists increase their understanding of these chromosomal disorders.
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