Chinese scientists reveal rapid anti-depression mechanism
February 22, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];On the 15th, two articles published by Nature and the journal from the Zhejiang University School of Medicine and the Qi Huo Institute of Higher Research, revealed the mechanism of action of rapid antidepressants and promoted the recognition of the pathogenesis of depression. Know, and provide a number of new molecular targets for the development of new fast-acting antidepressants.
Hu Haijun said that depression has become a disease affecting human life. More than 300 million people worldwide suffer from depression. However, treatment drugs often take weeks or even months to work, and only for some patients. “This means that our understanding of the mechanism of depression may not have touched the core.â€
In recent years, the scientific community has found that "ketamine" has a good therapeutic effect on depression. Low doses of ketamine can treat more than 70% of patients with refractory depression within one hour. Through the study of this mechanism of action, Hu Haijun's team found that the cluster discharge of the lateral nucleus of the cerebral palsy causes depression.
The lateral nucleus is a small nucleus below the hippocampus in the brain. It is the "anti-reward center" of the brain, which dominates negative emotions such as fear, tension, and anxiety, and inhibits the "reward center" in the brain.
"The lateral nucleus discharge pattern of normal mice is a single discharge, while the mice in depression exhibit cluster-like discharge behavior. From single discharge to cluster discharge, it is like a rifle shot to a machine gun shot. A more intensive and efficient way of transmitting electrical signals," Hu Haijun said.
Clustered discharges enhance the inhibition of the “reward center†by the lateral habenular nucleus, causing depressive symptoms. The reason why ketamine works quickly is because it prevents this special discharge. Although ketamine is highly effective, it is also a major limitation in clinical use because it is also a major component of anesthetics and drugs. Based on this, Hu Haijun team further identified a number of new rapid anti-depression molecular targets for blocking the cluster discharge.
“This research has a wide range of implications.†Inge, the science director of Nature, said that the study will be the basis for improving the effectiveness of treatment for depression. (Reporter Zhu Han)
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