Want to understand the whole process of the cell "rejuvenation"? Please scan the "QR code" on the chromatin
Recently, scientists have discovered that there is a “rejuvenation†switch on the chromatin in biological cells, and it looks like a two-dimensional code, which can record the whole process of “rejuvenationâ€.
Scientists used the ATAC-seq technology to read the "two-dimensional code" in the chromatographic "switch" state and found that the "switch" in the chromatin has a binary change during the fate transition. The information on the "two-dimensional code" has been changing throughout the stem cell induction process.
The discovery came from the research group of the Institute of Biomedicine and Health, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, in the process of stem cell induction. Scientists believe that by deciphering the intrinsic meaning of these "two-dimensional codes", we can understand the mechanism of change in the stem cell induction process, thus providing a new reference model for understanding cell reprogramming and studying other related cell fate transitions.
It is understood that after the induction factor is introduced into fibroblasts, the cell automatically initiates a series of "unknown procedures" to allow the aging somatic cells to "return" to about 3.5 days after fertilization. Scientists have been working hard for 10 years to explore this series of "unknown procedures."
Scientists say that every cell contains all the information about the individual, and DNA is like an encyclopedia that records all the changes in the cell. But at the moment, we have read only a part of this encyclopedia, there is no way to read through the whole book, and there is too little information about the process of cells to stem cells. Therefore, scientists have been looking for ways to find a good way to understand the whole process of cell changes.
Yan Duanqing said that this discovery reveals for the first time the dynamics of chromatin structure during somatic cell reprogramming and provides a good reference model for future research.
The small tube is a kind of squid, which is characterized by a small body and a long and slender body, also called the squid.
Squid meat is more delicious than cuttlefish. The head and torso are longer and narrower than that of a cuttlefish, especially the end of the torso are very similar to the spearhead of a javelin, so it is called a squid. Octopus, also known as octopus, belongs to the order of the eight arms.
Both octopuses and cuttlefish have ink sacs that can release the ink. The biggest difference is that the octopus has only 8 wrists, and the suction cup on the wrist does not have a handle or toothed ring.
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