These two medical technologies may shake the "cancer moon landing plan"

According to statistics, 90% of cancer-related deaths are caused by tumor metastasis. In most people's view, the metastasis process of tumors is probably like this: some cells undergo mutations during the process of proliferation, leading to uncontrolled cell growth and formation of tumors; in the process of continuous cell division and proliferation, new gene mutations continue Accumulation, until some day, some tumor cells accidentally acquired genetic mutations related to metastasis, tumor cells showed invasiveness; they spread along the blood vessels and transferred to the appropriate organs for cancer.

The "cancer moon landing plan" that is currently being carried out in various countries is also based on this theory. Everyone wants to understand, overcome and predict the drug resistance in cancer treatment by deep sequencing of the primary lesion. Of course, if the cancer cells that form metastases in other tissues and organs are from the tumor tissue that we sequenced and sampled, it would be fine. However, since 2002, studies have shown that (1-4), cancer cells leave the primary lesions at the very early stage of tumor formation, and they are independently camped on other tissues and organs. This means that I am afraid I will not talk about it.

Julio A. Professor Aguirre-Ghiso

However, the academic community has not always been aware of the secret behind the ultra-early transfer of tumor cells, so that there is no way to find a countermeasure. Finally, on December 14, Julio A. from the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, USA. Professor Aguirre-Ghiso (5) and Christoph A. of the University of Regensburg, Germany. Dr. Klein's team (6), co-published two articles online in Nature, and for the first time clarified the mechanism by which cancer cells spread early.

Surprisingly, they also found that cancer cells that spread out early in the tumor formation were more capable of colonizing the metastatic lesion than cancer cells that were spread after the tumor was formed. This has completely subverted our long-standing understanding of tumor metastasis. This means that we should focus more on the early stages of tumorigenesis and study mature tumors, which may not solve the problem fundamentally. Cyrus M., Fred Hutchinson Cancer Research Center Ghajar and Mina J. of Lawrence Berkeley National Laboratory Bissell jointly published an article on Nature to evaluate their important research progress (7).

Make an inappropriate analogy. When we classify startup companies, we often use the words Ali, Tencent, and Huada to classify some companies. The founders and core teams of these startups mostly started their business when Ali, Tencent and Huada were in a climate, so these companies have more or less the shadows of Ali, Tencent and Huada. We can even see you. When you are in the company, say a few of the features they might have.

Christoph A. Dr. Klein (orange tie)

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