Author: Shijun Bin Release Date: 2018-07-30
An injectable nano-composite gel-heavy hemostatic material with blood-triggered shape memory recovery was recently developed by Guo Baolin, a researcher at the Institute of Frontier Science and Technology of Xi'an Jiaotong University. The results were published in the latest international journal Nature Communication. .
Controlling bleeding is an important issue for military and civilian trauma centers worldwide, with uncontrolled bleeding leading to more than 30% of traumatic deaths, more than half of which occur before emergency care arrives. Although currently used hemostatic agents exhibit excellent performance in hemostasis of limb surface wounds, they are generally less effective in hemostasis of deep wound bleeding caused by gun shrapnel or explosive devices on the battlefield or in daily life.
Researchers at Xi'an Jiaotong University used a natural product chitosan with good biocompatibility and hemostatic properties as raw materials to simultaneously modify double bonds and quaternary ammonium salt groups in their main chain by one-pot reaction. The quaternary ammonium salt modification can not only improve the water solubility of chitosan but also enhance its antibacterial effect. The polymer solution was subjected to radical polymerization in a frozen state to prepare a crystal gel having a porous structure. Carbon nanotubes have also been introduced, which can improve the mechanical properties of the gelatin, impart good conductivity to the gelatin, and excellent near-infrared trigger response (eg, sustained release of analgesic drugs, photothermal sterilization, etc.). Studies have shown that the hemostatic material absorbs blood quickly when it comes into contact with blood. It can concentrate blood and accelerate the blood clotting process. At the same time, the expanded gelatin can block the wound as a physical barrier, thus showing good hemostasis for incompressible deep wound bleeding. effect. (Reporter Shi Junbin)
Source: Technology Daily
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