The bio-pharmaceutical industry, known as the "Chaoyang industry," has become one of the hot areas in which many investors and entrepreneurs are particularly concerned. The people of insight are competing to invest in the establishment of pharmaceutical factories, and they are seeking to obtain sustained and rapid development of the enterprise by adopting measures such as purchasing high value-added products with intellectual property rights and participating in the preliminary scientific research of biomedical products. However, faced with the challenge of strong competition, its operators must have the vision of a strategist, integrate the development of the enterprise with the development of the current science and technology, and explore the long-term and stable development of the enterprise. The integration of five new technologies? The rapid development and application of high and new technology in recent years has brought about a series of nearly revolutionary changes in the field of pharmaceutical research and production. The traditional research ideas and technologies have been far from meeting the needs of enterprises. Technology has become a routine means of daily scientific research and production. ? - Integration with computer technology. In drug molecule design, molecular structure optimization, etc., computer molecular simulation techniques and theoretical chemistry calculation methods are used to study the mechanism of action of drugs, and then computer-aided drug design methods are used to design new high-efficiency and low-toxic drug molecules, which greatly improves the speed of scientific research. And success rate. In the process of discovering effective chemical components, computer-aided screening techniques, known structural simulation techniques, three-dimensional structural docking techniques, molecular weight energy calculations, and molecular interaction force prediction methods are used to find effective combinations with specific drug targets. The molecular structure as a research object has greatly improved the relevance of scientific research. ? - Integration with biochip technology. With the progress of human genome research, the application of biochip technology in various fields is gradually becoming possible. Existing biochips include gene chips, protein chips, cell chips, tissue chips, and other information chips made of biological materials. At present, biochips are mainly used in the analysis and basic research of diseases. With the continuous maturation of this technology, there must be a wide range of application prospects in gene drug research, disease prevention, and treatment. ? - Integration with combinatorial chemical synthesis. Combinatorial chemistry involves the use of appropriate chemical methods to add different groups to specific molecular nucleus and produce large amounts of new compounds under the same conditions. The development of combinatorial chemistry technology provides a large number of compounds for the discovery of drugs, expanding the scope of drug discovery and increasing the likelihood of success. ? - Integration with nanotechnology. The application of nanotechnology in biomedicine can be summarized as: nanomedicine carriers, biological analysis, genetic engineering, or correction techniques. Among them, nano drug carriers are most widely used in medical research, and relevant technologies and clinical applications are relatively mature. Using nanotechnology, drug carriers and micro-devices made of biodegradable and biocompatible polymers have brought new breakthroughs in disease treatment, diagnosis, tissue repair, and artificial organs. Targeted drug preparations using nanomaterials or nanomagnetic techniques as carriers have become a reality in the treatment of cancer. The application of nanotechnology in the assembly of biological macromolecules allows us to change the protein lattice of the cell surface layer, which has significant application value in disease diagnosis, immunization vaccines, bionics and molecular biology techniques. ? - Integration with high-throughput screening technologies. Drug discovery is the basis of drug research. Drug screening is the evaluation of the pharmacological and physiological values ​​of substances that may be used as drugs, and the discovery of drugs. Increasing the screening speed and scale is a prerequisite for increasing the quantity and quality of drug discovery. High-throughput screening technology combines the development of molecular pharmacology, molecular biology, cell biology, human genomics and molecular pathology, and uses molecular and cellular level research methods to explore the role of drugs and increase drug screening methods. This allows us to evaluate drugs without relying solely on animal experiments. While the amount of sample and the experimental system are greatly reduced, drug screening is performed on a large scale. Integrate intellectual property protection In the face of increasingly fierce competition in the pharmaceutical market, innovation is the ultimate outlet for China's pharmaceutical industry, and innovation must be combined with intellectual property protection to consolidate its own market and ensure scale-effectiveness-the benignity of new innovation. cycle. Technical barriers, technical barriers, and intellectual property protection will be important means to strengthen industrial competitiveness. Intellectual property should not be an expedient measure, but should be an important part of the company's strategy. The following four points need to be taken into account in the integration of IP protection means: 1. First, the protection of intellectual property rights of new pharmaceutical products. In the research process of new products, according to the progress of the situation, select the right time to submit a patent application. After the completion of the development, all applications for patent applications should be filed in time, such as compound patents, use patents, etc. For existing compound patents, relevant subordinate patents should be obtained as far as possible. The second is the protection of intellectual property rights of existing drugs. Innovation is not limited to variety innovation. New uses of known products, new quality indicators, and new exterior packaging can all be patent protected. Only from the appearance of the patent, it can be the color, shape, pattern or combination of the drug itself, or the color, shape, pattern or combination of the inner package directly in contact with the drug, or the color of the outer package. , shapes, patterns, or combinations thereof. In addition, companies can also apply the utility model patent protection to the structure of the product according to the patent law. The third is to make full use of various means to protect intellectual property rights. For example, the protection of intellectual property rights of Chinese medicine is subject to state administrative protection as the mainstream measure, but such protection does not have exclusive rights. Since patents take several years to process, Chinese medicine patents can be easily imitated and administratively protected by others in the public phase. Finally, we must pay attention to preventing the loss of intellectual property rights caused by the flow of employees. Of course, compared with the international giants, China's bio-pharmaceutical industry has great disparities in its capital strength, R&D capabilities, and market control capabilities, and it lacks the ability to participate in international competition. Therefore, we must accurately locate and accelerate industrial adjustment. In the initial stage, economies of scale can be achieved through the reform and restructuring of state-owned enterprises, or they can consider their own advantages, choose favorable projects, and actively participate in the restructuring of multinational companies. In short, pharmaceutical companies must integrate various types of advanced knowledge, track the forefront of scientific development, and strive to improve their competitiveness.
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